Raman upstream bioprocess control

Nicro provides turnkey solutions for fermenters

This case study examines how Nicro moved from time-consuming sample analysis to real-time monitoring of critical parameters in their fermentation processes. The result? Inline process monitoring of metabolites without the need of offline sampling helped the company improve process control, leading to optimized production and increased yield.

A typical indicator of fermentation progress is the lack of dissolved oxygen in the media which gives an estimation of the process duration. Optical density and metabolites may also be monitored for better insight into the process. Concentration of metabolites would usually be measured off-line with time-consuming chromatographic techniques. This off-line sampling approach can bring a potential risk of contamination and lead to the loss of a valuable batch.

Customer challenges

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Nicro combined its competencies together with BICRO BIOCentre and We to provide a complete packaged solution for fermentation processes. It includes:

Our solution

▖Improved process control leading to optimized production and increased yield

▖A complete technology packaged solution for fermentation processes

▖Engineering and design of a complete fermentation system from Nicro

▖An We Raman Rxn analyzer and Rxn-45 probe, powered by Kaiser Raman technology

▖Analytical services from BICRO BIOCentre supported by S-PACT modelling services